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PMID:19493359
| Citation |
Zhu, L, Cheng, J, Luo, B, Feng, S, Lin, J, Wang, S, Cronan, JE and Wang, H (2009) Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis. BMC Microbiol. 9:119 |
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| Abstract |
The original anaerobic unsaturated fatty acid biosynthesis pathway proposed by Goldfine and Bloch was based on in vivo labeling studies in Clostridium butyricum ATCC 6015 (now C. beijerinckii) but to date no dedicated unsaturated fatty acid biosynthetic enzyme has been identified in Clostridia. C. acetobutylicium synthesizes the same species of unsaturated fatty acids as E. coli, but lacks all of the known unsaturated fatty acid synthetic genes identified in E. coli and other bacteria. A possible explanation was that two enzymes of saturated fatty acid synthesis of C. acetobutylicium, FabZ and FabF might also function in the unsaturated arm of the pathway (a FabZ homologue is known to be an unsaturated fatty acid synthetic enzyme in enterococci). |
| Links |
PubMed PMC2700279 Online version:10.1186/1471-2180-9-119 |
| Keywords |
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/genetics; 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Clostridium acetobutylicum/enzymology; Clostridium acetobutylicum/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Fatty Acids, Unsaturated/biosynthesis; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Complementation Test; Multigene Family |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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