GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:19481459
| Citation |
Walker, CS, Jensen, S, Ellison, M, Matta, JA, Lee, WY, Imperial, JS, Duclos, N, Brockie, PJ, Madsen, DM, Isaac, JT, Olivera, B and Maricq, AV (2009) A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr. Biol. 19:900-8 |
|---|---|
| Abstract |
Ionotropic glutamate receptors (iGluRs) are glutamate-gated ion channels that mediate excitatory neurotransmission in the central nervous system. Based on both molecular and pharmacological criteria, iGluRs have been divided into two major classes, the non-NMDA class, which includes both AMPA and kainate subtypes of receptors, and the NMDA class. One evolutionarily conserved feature of iGluRs is their desensitization in the continued presence of glutamate. Thus, when in a desensitized state, iGluRs can be bound to glutamate, yet the channel remains closed. However, the relevance of desensitization to nervous system function has remained enigmatic. |
| Links |
PubMed PMC2722447 Online version:10.1016/j.cub.2009.05.017 |
| Keywords |
Animals; Benzothiadiazines/pharmacology; Binding Sites; Chemical Fractionation; Chromatography, High Pressure Liquid; Conus Snail/chemistry; Conus Snail/metabolism; Dimerization; Electric Conductivity; Hippocampus/drug effects; Mollusk Venoms/chemistry; Neurotoxins/chemistry; Neurotoxins/isolation & purification; Neurotoxins/pharmacology; Patch-Clamp Techniques; Peptides/chemistry; Peptides/isolation & purification; Peptides/pharmacology; Rats; Receptors, AMPA/chemistry; Receptors, AMPA/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/isolation & purification; Recombinant Proteins/pharmacology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xenopus |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004970: ionotropic glutamate receptor activity |
ECO:0000314: |
F |
Fig 4. Con-ikot-ikot specifically targets a subset of iGluRs. |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
