GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:19436747
| Citation |
Retamal, P, Castillo-Ruiz, M and Mora, GC (2009) Characterization of MgtC, a virulence factor of Salmonella enterica Serovar Typhi. PLoS ONE 4:e5551 |
|---|---|
| Abstract |
The MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI-3 of S. Typhi for growth in low-Mg2+ media and survival within human cells. In addition, by using reporter genes we determined that the low-Mg2+ concentration, acidic media and PhoP regulator induce mgtC expression in S. Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi. |
| Links |
PubMed PMC2677668 Online version:10.1371/journal.pone.0005551 |
| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cation Transport Proteins/genetics; Cation Transport Proteins/metabolism; Conserved Sequence; Genes, Bacterial; Genes, Reporter; Magnesium/metabolism; Phenotype; Salmonella typhi/growth & development; Salmonella typhi/metabolism; Salmonella typhi/pathogenicity; Virulence Factors/genetics; Virulence Factors/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0009405: pathogenesis |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0009405: pathogenesis |
ECO:0000315: |
P |
Figure 2. MgtC mutants showed decreased survival in human cells as compared to the WT |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
