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PMID:18624975
| Citation |
Hsu, CC, Wu, WB and Huang, TF (2008) A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions. J. Thromb. Haemost. 6:1578-85 |
|---|---|
| Abstract |
Injuries to the vessel wall and subsequent exposure of the matrix of the subendothelial layer resulted in thrombus formation. Platelet glycoprotein (GP) Ib and VI play a crucial role in matrix-induced activation and aggregation of platelets. |
| Links |
PubMed Online version:10.1111/j.1538-7836.2008.03071.x |
| Keywords |
Antigens, CD36/metabolism; Blood Platelets/cytology; Blood Platelets/drug effects; Blood Platelets/metabolism; Cell Adhesion; Collagen/metabolism; Crotalid Venoms/metabolism; Crotalid Venoms/pharmacology; Flow Cytometry; Humans; Hydrolysis; Metalloproteases/metabolism; Metalloproteases/pharmacology; Phosphorylation; Platelet Aggregation Inhibitors/metabolism; Platelet Aggregation Inhibitors/pharmacology; Recombinant Proteins/metabolism; Tyrosine/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0008233: peptidase activity |
ECO:0000314: |
F |
Fig. 2B and 3 |
complete | ||||
| GO:0035893: negative regulation of platelet aggregation in other organism |
ECO:0000314: |
P |
Fig. 1 |
complete | ||||
|
enables |
GO:0008233: peptidase activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035893: negative regulation of platelet aggregation in other organism |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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