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PMID:18573169
| Citation |
Fukushima, T, Szurmant, H, Kim, EJ, Perego, M and Hoch, JA (2008) A sensor histidine kinase co-ordinates cell wall architecture with cell division in Bacillus subtilis. Mol. Microbiol. 69:621-32 |
|---|---|
| Abstract |
The concerted interconnection between processes driving DNA synthesis, division septum formation and cell wall synthesis and remodelling in rapidly growing bacteria requires precise co-ordination by signalling mechanisms that are, for the most part, unknown. The YycG (sensor histidine kinase)-YycF (response regulator/transcription factor) two-component system of Bacillus subtilis controls the synthesis of enzymes and their inhibitors that function in cell wall remodelling and cell separation. Here it is shown that the YycG sensor histidine kinase is a component of the division septum in growing cells. RT-PCR quantification of YycF approximately PO(4)-regulated gene transcription, in wild type and FtsZ-depleted, septum-less cells, indicated that YycG kinase activity on YycF is dependent on YycG localization to a division septum. The data support a model in which the YycG sensor kinase perceives information at the division septum and regulates the reciprocal synthesis of autolysins and autolysin inhibitors to co-ordinate growth and division with cell wall restructuring. |
| Links |
PubMed PMC2574549 Online version:10.1111/j.1365-2958.2008.06308.x |
| Keywords |
Bacillus subtilis/chemistry; Bacillus subtilis/enzymology; Bacillus subtilis/genetics; Bacillus subtilis/physiology; Bacterial Proteins/analysis; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cell Division; Cell Nucleolus/enzymology; Cell Wall/enzymology; Cell Wall/genetics; Cell Wall/physiology; Protein Kinases/analysis; Protein Kinases/genetics; Protein Kinases/metabolism; Signal Transduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0030428: cell septum |
ECO:0000314: |
C |
Figure 1. |
complete | ||||
|
part_of |
GO:0030428: cell septum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0009295: nucleoid |
ECO:0000315: |
C |
Figure 5. |
complete | ||||
| GO:0006355: regulation of transcription, DNA-dependent |
ECO:0000270: |
P |
Figure 6B. |
complete | ||||
|
involved_in |
GO:0006355: regulation of transcription, DNA-templated |
ECO:0000270: expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009295: nucleoid |
ECO:0000315: mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0051301: cell division |
ECO:0000315: |
P |
Fig. 2 |
complete | ||||
| GO:0030428: cell septum |
ECO:0000314: |
C |
Fig. 1 |
complete | ||||
|
part_of |
GO:0030428: cell septum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301: cell division |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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