GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:18515547
| Citation |
Nykamp, K, Lee, MH and Kimble, J (2008) C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis. RNA 14:1378-89 |
|---|---|
| Abstract |
RNA regulators are critical for animal development, especially in the germ line where gene expression is often modulated by changes in mRNA stability, translation, and localization. In this paper, we focus on Caenorhabditis elegans LARP-1, a representative of one La-related protein (Larp) family found broadly among eukaryotes. LARP-1 possesses a signature La motif, which is an ancient RNA-binding domain, plus a second conserved motif, typical of LARP-1 homologs and therefore dubbed the LARP1 domain. LARP-1 appears to bind RNA in vitro via both the La motif and the LARP1 domain. larp-1 null mutants have an oogenesis defect reminiscent of hyperactive Ras-MAPK signaling; this defect is suppressed or enhanced by down- or up-regulating the Ras-MAPK pathway, respectively. Consistent with a role in down-regulating the Ras-MAPK pathway, larp-1 null mutants have higher than normal levels of selected pathway mRNAs and proteins. LARP-1 protein colocalizes with P bodies, which function in RNA degradation. We suggest that LARP-1 functions in P bodies to attenuate the abundance of conserved Ras-MAPK mRNAs. We also propose that the cluster of LARP-1 homologs may function generally to control the expression of key developmental regulators. |
| Links |
PubMed PMC2441978 Online version:10.1261/rna.1066008 |
| Keywords |
Animals; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/analysis; Caenorhabditis elegans Proteins/metabolism; Cytoplasm/chemistry; Germ Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1/metabolism; Oogenesis; Phylogeny; RNA-Binding Proteins/analysis; RNA-Binding Proteins/metabolism; ras Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
