PMID:18467592

Citation	Prahlad, V, Cornelius, T and Morimoto, RI (2008) Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 320:811-4
Abstract	Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change.
Links	PubMed PMC3429343 Online version:10.1126/science.1156093
Keywords	Animals; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/physiology; Genes, Helminth; Heat-Shock Proteins/genetics; Heat-Shock Proteins/physiology; Heat-Shock Response/genetics; Heat-Shock Response/physiology; Models, Neurological; Mutation; Neurons, Afferent/physiology; Pheromones/physiology; Protein Folding; Thermosensing/physiology; Transcription Factors/genetics; Transcription Factors/physiology
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