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PMID:18050905
| Citation |
Kim, KM, Jun, DY, Kim, SK, Kim, CK, Kim, BO, Kim, YH, Park, W, Sohn, JK, Hirata, A, Kawai-Yamada, M, Uchimiya, H, Kim, DH and Sul, IW (2007) Identification of novel mitochondrial membrane protein (Cdf 3) from Arabidopsis thaliana and its functional analysis in a yeast system. J. Microbiol. Biotechnol. 17:891-6 |
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| Abstract |
We screened the Arabidopsis cDNA library to identify functional suppressors of AtBI-1, a gene that suppresses cell death induced by Bax gene expression in yeast. Cdf 3 encodes a 118-amino-acid protein with a molecular mass of 25 kDa. This protein has two uncharacterized domains at amino acids residues 5-64 and 74-117. In the present study, CDF3 was found to induce growth defects in yeast and arrested yeast growth, although the cell-growth defect was somewhat less than that of Bax. Its localization in the inner mitochondria was essential for suppression of yeast-cell proliferation. The morphological abnormality of the intracellular network, which is a hallmark of AtBI-1, was attenuated by Cdf 3 expression. |
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| Keywords |
Amino Acid Sequence; Apoptosis; Arabidopsis/genetics; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/physiology; Base Sequence; Gene Library; Genes, Plant; Membrane Proteins/genetics; Membrane Proteins/physiology; Mitochondrial Membranes/chemistry; Molecular Sequence Data; Saccharomyces cerevisiae/genetics; bcl-2-Associated X Protein/genetics |
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Significance
Annotations
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