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PMID:18004212
| Citation |
Girard, H, Lévesque, E, Bellemare, J, Journault, K, Caillier, B and Guillemette, C (2007) Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Pharmacogenet. Genomics 17:1077-89 |
|---|---|
| Abstract |
The gene UGT1 encodes phase II detoxification proteins involved in the elimination of small hydrophobic substances of both endogenous and exogenous origin. To date, nine functional UGT1A proteins are known to be produced from a single gene composed of alternative first exons shared with four common exons. Recently, a novel exon (referred to as exon 5b) was identified in the common shared region. |
| Links |
PubMed Online version:10.1097/FPC.0b013e3282f1f118 |
| Keywords |
Alternative Splicing; Animals; Base Sequence; Cell Line; DNA Primers/genetics; DNA, Complementary/genetics; Exons; Genetic Variation; Glucuronides/metabolism; Glucuronosyltransferase/genetics; Glucuronosyltransferase/metabolism; Humans; Macaca fascicularis; Models, Genetic; Pharmacogenetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Tissue Distribution; Transfection |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2001030: negative regulation of cellular glucuronidation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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