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PMID:17925224
| Citation |
Haynes, CM, Petrova, K, Benedetti, C, Yang, Y and Ron, D (2007) ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev. Cell 13:467-80 |
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| Abstract |
The cellular response to unfolded and misfolded proteins in the mitochondrial matrix is poorly understood. Here, we report on a genome-wide RNAi-based screen for genes that signal the mitochondrial unfolded protein response (UPR(mt)) in C. elegans. Unfolded protein stress in the mitochondria correlates with complex formation between a homeodomain-containing transcription factor DVE-1 and the small ubiquitin-like protein UBL-5, both of which are encoded by genes required for signaling the UPR(mt). Activation of the UPR(mt) correlates temporally and spatially with nuclear redistribution of DVE-1 and with its enhanced binding to the promoters of mitochondrial chaperone genes. These events and the downstream UPR(mt) are attenuated in animals with reduced activity of clpp-1, which encodes a mitochondrial matrix protease homologous to bacterial ClpP. As ClpP is known to function in the bacterial heat-shock response, our findings suggest that eukaryotes utilize component(s) from the protomitochondrial symbiont to signal the UPR(mt). |
| Links |
PubMed Online version:10.1016/j.devcel.2007.07.016 |
| Keywords |
Animals; Animals, Genetically Modified; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Nucleus/metabolism; Embryo, Nonmammalian; Endopeptidase Clp/genetics; Endopeptidase Clp/metabolism; Escherichia coli Proteins/genetics; Genome, Helminth; Mitochondria/metabolism; Molecular Chaperones/genetics; Molecular Chaperones/metabolism; Mutation; Promoter Regions, Genetic; Protein Folding; Signal Transduction; Transcription Factors/metabolism; Ubiquitins/genetics; Ubiquitins/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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