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PMID:17919906
| Citation |
Wang, D, Pajerowska-Mukhtar, K, Culler, AH and Dong, X (2007) Salicylic acid inhibits pathogen growth in plants through repression of the auxin signaling pathway. Curr. Biol. 17:1784-90 |
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| Abstract |
The phytohormone auxin regulates almost every aspect of plant development. At the molecular level, auxin induces gene expression through direct physical interaction with the TIR1-like F box proteins, which in turn remove the Aux/IAA family of transcriptional repressors [1-4]. A growing body of evidence indicates that many plant pathogens can either produce auxin themselves or manipulate host auxin biosynthesis to interfere with the host's normal developmental processes [5-11]. In response, plants probably evolved mechanisms to repress auxin signaling during infection as a defense strategy. Plants overaccumulating the defense signal molecule salicylic acid (SA) frequently display morphological phenotypes that are reminiscent of auxin-deficient or auxin-insensitive mutants, indicating that SA might interfere with auxin responses. By using the Affymetrix ATH1 GeneChip for Arabidopsis thaliana, we performed a comprehensive study of the effects of SA on auxin signaling [12]. We found that SA causes global repression of auxin-related genes, including the TIR1 receptor gene, resulting in stabilization of the Aux/IAA repressor proteins and inhibition of auxin responses. We demonstrate that this inhibitory effect on auxin signaling is a part of the SA-mediated disease-resistance mechanism. |
| Links |
PubMed Online version:10.1016/j.cub.2007.09.025 |
| Keywords |
Arabidopsis/drug effects; Arabidopsis/genetics; Arabidopsis/physiology; Gene Expression Profiling; Genes, Plant/drug effects; Indoleacetic Acids/metabolism; Mutation; Oligonucleotide Array Sequence Analysis; Plant Diseases/genetics; Plant Growth Regulators/physiology; Plants, Genetically Modified; Salicylic Acid/metabolism; Salicylic Acid/pharmacology; Signal Transduction/drug effects; Thiadiazoles/pharmacology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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