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PMID:17683539
| Citation |
Lee, HC, Tsai, JN, Liao, PY, Tsai, WY, Lin, KY, Chuang, CC, Sun, CK, Chang, WC and Tsai, HJ (2007) Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo. BMC Dev. Biol. 7:93 |
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| Abstract |
Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine protein kinase, is known to play roles in many biological processes. Two closely related GSK3 isoforms encoded by distinct genes: GSK3alpha (51 kDa) and GSK3beta (47 kDa). In previously studies, most GSK3 inhibitors are not only inhibiting GSK3, but are also affecting many other kinases. In addition, because of highly similarity in amino acid sequence between GSK3alpha and GSK3beta, making it difficult to identify an inhibitor that can be selective against GSK3alpha or GSK3beta. Thus, it is relatively difficult to address the functions of GSK3 isoforms during embryogenesis. At this study, we attempt to specifically inhibit either GSK3alpha or GSK3beta and uncover the isoform-specific roles that GSK3 plays during cardiogenesis. |
| Links |
PubMed PMC1988812 Online version:10.1186/1471-213X-7-93 |
| Keywords |
Animals; Animals, Genetically Modified; Apoptosis; Blotting, Western; Embryo, Nonmammalian; Glycogen Synthase Kinase 3/antagonists & inhibitors; Glycogen Synthase Kinase 3/genetics; Heart/embryology; Isoenzymes/antagonists & inhibitors; Isoenzymes/genetics; Myocytes, Cardiac/cytology; Myocytes, Cardiac/enzymology; RNA, Messenger; Zebrafish/embryology; Zebrafish/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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