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PMID:17637677
| Citation |
Thines, B, Katsir, L, Melotto, M, Niu, Y, Mandaokar, A, Liu, G, Nomura, K, He, SY, Howe, GA and Browse, J (2007) JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling. Nature 448:661-5 |
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| Abstract |
Jasmonate and related signalling compounds have a crucial role in both host immunity and development in plants, but the molecular details of the signalling mechanism are poorly understood. Here we identify members of the jasmonate ZIM-domain (JAZ) protein family as key regulators of jasmonate signalling. JAZ1 protein acts to repress transcription of jasmonate-responsive genes. Jasmonate treatment causes JAZ1 degradation and this degradation is dependent on activities of the SCF(COI1) ubiquitin ligase and the 26S proteasome. Furthermore, the jasmonoyl-isoleucine (JA-Ile) conjugate, but not other jasmonate-derivatives such as jasmonate, 12-oxo-phytodienoic acid, or methyl-jasmonate, promotes physical interaction between COI1 and JAZ1 proteins in the absence of other plant proteins. Our results suggest a model in which jasmonate ligands promote the binding of the SCF(COI1) ubiquitin ligase to and subsequent degradation of the JAZ1 repressor protein, and implicate the SCF(COI1)-JAZ1 protein complex as a site of perception of the plant hormone JA-Ile. |
| Links |
PubMed Online version:10.1038/nature05960 |
| Keywords |
Amino Acid Sequence; Arabidopsis/drug effects; Arabidopsis/genetics; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Cell-Free System; Cyclopentanes/pharmacology; Genes, Plant/genetics; Glucuronidase/genetics; Glucuronidase/metabolism; Isoleucine/analogs & derivatives; Isoleucine/pharmacology; Molecular Sequence Data; Multigene Family/genetics; Oxylipins; Phenotype; Protein Binding; Protein Structure, Tertiary; Repressor Proteins/chemistry; Repressor Proteins/genetics; Repressor Proteins/metabolism; SKP Cullin F-Box Protein Ligases/metabolism; Signal Transduction/drug effects; Substrate Specificity |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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