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PMID:17517120
| Citation |
Na, J, Tunggal, B and Eichinger, L (2007) STATc is a key regulator of the transcriptional response to hyperosmotic shock. BMC Genomics 8:123 |
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| Abstract |
Dictyostelium discoideum is frequently subjected to environmental changes in its natural habitat, the forest soil. In order to survive, the organism had to develop effective mechanisms to sense and respond to such changes. When cells are faced with a hypertonic environment a complex response is triggered. It starts with signal sensing and transduction and leads to changes in cell shape, the cytoskeleton, transport processes, metabolism and gene expression. Certain aspects of the Dictyostelium osmotic stress response have been elucidated, however, no comprehensive picture was available up to now. |
| Links |
PubMed PMC1888708 Online version:10.1186/1471-2164-8-123 |
| Keywords |
Actins/metabolism; Animals; Blotting, Northern; Cluster Analysis; Dictyostelium/drug effects; Dictyostelium/genetics; Dictyostelium/metabolism; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation/drug effects; Microscopy, Confocal; Oligonucleotide Array Sequence Analysis; Osmotic Pressure; Protozoan Proteins/genetics; Protozoan Proteins/physiology; STAT Transcription Factors/genetics; STAT Transcription Factors/physiology; Sorbitol/pharmacology; Time Factors; Transcription, Genetic |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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