PMID:17347412

Citation	Liu, X, Yue, Y, Li, B, Nie, Y, Li, W, Wu, WH and Ma, L (2007) A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science 315:1712-6
Abstract	The plant hormone abscisic acid (ABA) regulates many physiological and developmental processes in plants. The mechanism of ABA perception at the cell surface is not understood. Here, we report that a G protein-coupled receptor genetically and physically interacts with the G protein alpha subunit GPA1 to mediate all known ABA responses in Arabidopsis. Overexpressing this receptor results in an ABA-hypersensitive phenotype. This receptor binds ABA with high affinity at physiological concentration with expected kinetics and stereospecificity. The binding of ABA to the receptor leads to the dissociation of the receptor-GPA1 complex in yeast. Our results demonstrate that this G protein-coupled receptor is a plasma membrane ABA receptor.
Links	PubMed Online version:10.1126/science.1135882
Keywords	Abscisic Acid/metabolism; Abscisic Acid/pharmacology; Arabidopsis/genetics; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; GTP-Binding Protein alpha Subunits/metabolism; Gene Expression Profiling; Genes, Reporter; Germination; Models, Biological; Mutation; Plant Growth Regulators/metabolism; Plant Leaves/cytology; Plant Leaves/physiology; Plants, Genetically Modified; Potassium Channels/metabolism; Protein Binding; Receptors, G-Protein-Coupled/chemistry; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Recombinant Proteins/metabolism; Seeds/growth & development; Signal Transduction
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