PMID:17307924

Citation	Aguilar-Martínez, JA, Poza-Carrión, C and Cubas, P (2007) Arabidopsis BRANCHED1 acts as an integrator of branching signals within axillary buds. Plant Cell 19:458-72
Abstract	Shoot branching patterns depend on a key developmental decision: whether axillary buds grow out to give a branch or whether they remain dormant in the axils of leaves. This decision is controlled by endogenous and environmental stimuli mediated by hormonal signals. Although genes involved in the long-distance signaling of this process have been identified, the genes responding inside the buds to cause growth arrest remained unknown in Arabidopsis thaliana. Here, we describe an Arabidopsis gene encoding a TCP transcription factor closely related to teosinte branched1 (tb1) from maize (Zea mays), BRANCHED1 (BRC1), which represents a key point at which signals controlling branching are integrated within axillary buds. BRC1 is expressed in developing buds, where it arrests bud development. BRC1 downregulation leads to branch outgrowth. BRC1 responds to developmental and environmental stimuli controlling branching and mediates the response to these stimuli. Mutant and expression analyses suggest that BRC1 is downstream of the MORE AXILLARY GROWTH pathway and that it is required for auxin-induced apical dominance. Therefore, BRC1 acts inside the buds as an integrator of signals controlling bud outgrowth and translates them into a response of cell growth arrest. The conservation of BRC1/tb1 function among distantly related angiosperm species suggests that a single ancestral mechanism of branching control integration evolved before the radiation of flowering plants.
Links	PubMed PMC1867329 Online version:10.1105/tpc.106.048934
Keywords	Arabidopsis/anatomy & histology; Arabidopsis/genetics; Arabidopsis/growth & development; Arabidopsis Proteins/classification; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Flowers/growth & development; Flowers/ultrastructure; Gene Expression Regulation, Plant; Genes, Plant; Indoleacetic Acids/metabolism; Molecular Sequence Data; Mutation; Phenotype; Phylogeny; Plant Leaves/growth & development; Plant Leaves/ultrastructure; Plant Proteins/genetics; Plant Proteins/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Signal Transduction/genetics; Signal Transduction/physiology; Transcription Factors/classification; Transcription Factors/genetics; Transcription Factors/metabolism
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