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PMID:17289961
| Citation |
Chartrel, N, Alvear-Perez, R, Leprince, J, Iturrioz, X, Reaux-Le Goazigo, A, Audinot, V, Chomarat, P, Coge, F, Nosjean, O, Rodriguez, M, Galizzi, JP, Boutin, JA, Vaudry, H and Llorens-Cortes, C (2007) Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science 315:766; author reply 766 |
|---|---|
| Abstract |
Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39. |
| Links |
PubMed Online version:10.1126/science.1135047 |
| Keywords |
Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Calcium/metabolism; Cell Membrane/metabolism; Cricetinae; Cricetulus; Cyclic AMP/metabolism; Forskolin/pharmacology; Ghrelin; Humans; Ligands; Molecular Sequence Data; Peptide Hormones/genetics; Peptide Hormones/metabolism; Peptide Hormones/pharmacology; Pituitary Gland/cytology; Pituitary Gland/metabolism; Protein Binding; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Transfection |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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See also
References
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