GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:17227549
| Citation |
Culligan, KM, Robertson, CE, Foreman, J, Doerner, P and Britt, AB (2006) ATR and ATM play both distinct and additive roles in response to ionizing radiation. Plant J. 48:947-61 |
|---|---|
| Abstract |
The ATR and ATM protein kinases are known to be involved in a wide variety of responses to DNA damage. The Arabidopsis thaliana genome includes both ATR and ATM orthologs, and plants with null alleles of these genes are viable. Arabidopsis atr and atm mutants display hypersensitivity to gamma-irradiation. To further characterize the roles of ATM and ATR in response to ionizing radiation, we performed a short-term global transcription analysis in wild-type and mutant lines. We found that hundreds of genes are upregulated in response to gamma-irradiation, and that the induction of virtually all of these genes is dependent on ATM, but not ATR. The transcript of CYCB1;1 is unique among the cyclin transcripts in being rapidly and powerfully upregulated in response to ionizing radiation, while other G(2)-associated transcripts are suppressed. We found that both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. We propose that this upregulation of CYCB1;1 does not reflect the accumulation of cells in G(2), but instead reflects a still unknown role for this cyclin in DNA damage response. |
| Links |
PubMed Online version:10.1111/j.1365-313X.2006.02931.x |
| Keywords |
Arabidopsis/genetics; Arabidopsis/physiology; Arabidopsis/radiation effects; Arabidopsis Proteins/genetics; Arabidopsis Proteins/physiology; Cell Cycle/radiation effects; Cell Cycle Proteins/physiology; Cyclin B/genetics; DNA Damage/radiation effects; DNA, Plant/radiation effects; Gamma Rays; Gene Expression Regulation, Plant/radiation effects; Protein-Serine-Threonine Kinases/physiology; Transcription, Genetic/radiation effects; Up-Regulation |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
