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PMID:17176473
| Citation |
Invernizzi, CF, Xie, B, Richard, S and Wainberg, MA (2006) PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA. Retrovirology 3:93 |
|---|---|
| Abstract |
The HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNA through interaction with the Rev response element (RRE) by means of an arginine rich motif that is similar to the one found in Tat. Since Tat is known to be asymmetrically arginine dimethylated by protein arginine methyltransferase 6 (PRMT6) in its arginine rich motif, we investigated whether the Rev protein could act as a substrate for this enzyme. |
| Links |
PubMed PMC1779295 Online version:10.1186/1742-4690-3-93 |
| Keywords |
Active Transport, Cell Nucleus; Cell Nucleus/metabolism; Gene Expression Regulation, Viral; Gene Products, rev/genetics; Gene Products, rev/metabolism; Genes, rev; HIV-1/genetics; HIV-1/metabolism; HeLa Cells; Humans; Methylation; Nuclear Proteins/metabolism; Protein-Arginine N-Methyltransferases/metabolism; RNA, Viral/genetics; RNA, Viral/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; rev Gene Products, Human Immunodeficiency Virus |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016274: protein-arginine N-methyltransferase activity |
ECO:0000314: |
F |
Figure 4 |
complete | ||||
See also
References
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