PMID:17079269

Citation	Wada, H, Tanaka, H, Nakayama, S, Iwasaki, M and Okamoto, H (2006) Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development 133:4749-59
Abstract	Migration of neurons from their birthplace to their final target area is a crucial step in brain development. Here, we show that expression of the off-limits/frizzled3a (olt/fz3a) and off-road/celsr2 (ord/celsr2) genes in neuroepithelial cells maintains the facial (nVII) motor neurons near the pial surface during their caudal migration in the zebrafish hindbrain. In the absence of olt/fz3a expression in the neuroepithelium, nVII motor neurons extended aberrant radial processes towards the ventricular surface and mismigrated radially to the dorsomedial part of the hindbrain. Our findings reveal a novel role for these genes, distinctive from their already known functions, in the regulation of the planar cell polarity (i.e. preventing integration of differentiated neurons into the neuroepithelial layer). This contrasts markedly with their reported role in reintegration of neuroepithelial daughter cells into the neuroepithelial layer after cell division.
Links	PubMed Online version:10.1242/dev.02665
Keywords	Animals; Animals, Genetically Modified; Cadherins/genetics; Cadherins/metabolism; Cell Movement/genetics; Cell Movement/physiology; Frizzled Receptors/genetics; Frizzled Receptors/metabolism; Gene Expression Regulation, Developmental; Motor Neurons/cytology; Motor Neurons/metabolism; Mutation; Neuroepithelial Cells/cytology; Neuroepithelial Cells/metabolism; Rhombencephalon/embryology; Rhombencephalon/metabolism; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism
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