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Wang, J, Nagy, A, Larsson, J, Dudas, M, Sucov, HM and Kaartinen, V (2006) Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev. Biol. 6:51
Congenital cardiovascular diseases are the most common form of birth defects in humans. A substantial portion of these defects has been associated with inappropriate induction, migration, differentiation and patterning of pluripotent cardiac neural crest stem cells. While TGF-beta-superfamily signaling has been strongly implicated in neural crest cell development, the detailed molecular signaling mechanisms in vivo are still poorly understood.
Activin Receptors, Type I/deficiency; Activin Receptors, Type I/genetics; Activin Receptors, Type I/physiology; Animals; Aorta/abnormalities; Aorta/embryology; Apoptosis/genetics; Branchial Region/abnormalities; Branchial Region/embryology; Cell Movement/genetics; Female; Heart Defects, Congenital/embryology; Heart Defects, Congenital/genetics; Mice; Mice, Knockout; Mice, Transgenic; Neural Crest/embryology; Neural Crest/pathology; Protein-Serine-Threonine Kinases; Receptors, Transforming Growth Factor beta/deficiency; Receptors, Transforming Growth Factor beta/genetics; Receptors, Transforming Growth Factor beta/physiology; Signal Transduction/genetics
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