GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16873728
| Citation |
Ohashi, M, Runge, MS, Faraci, FM and Heistad, DD (2006) MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 26:2331-6 |
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| Abstract |
In mice that are heterozygous for mitochondrial superoxide dismutase (SOD2(+/-)) with apoE deficiency (apoE(-/-)), mitochondrial DNA damage increases formation of atherosclerotic lesions. The purpose of this study was to determine whether SOD2 provides protection against increased vascular superoxide and endothelial dysfunction in apoE-deficient mice. |
| Links |
PubMed Online version:10.1161/01.ATV.0000238347.77590.c9 |
| Keywords |
Animals; Aorta/enzymology; Aorta/metabolism; Aorta/pathology; Aorta/physiopathology; Apolipoproteins E/deficiency; Atherosclerosis/etiology; Atherosclerosis/pathology; Carotid Arteries/enzymology; Carotid Arteries/metabolism; Carotid Arteries/pathology; Carotid Arteries/physiopathology; Cholesterol/blood; Endothelium, Vascular/enzymology; Endothelium, Vascular/physiopathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Superoxide Dismutase/deficiency; Superoxides/metabolism; Tunica Intima/pathology; Vasomotor System/physiopathology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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