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PMID:16567561
| Citation |
Tanzer, JM, Thompson, A, Wen, ZT and Burne, RA (2006) Streptococcus mutans: fructose transport, xylitol resistance, and virulence. J. Dent. Res. 85:369-73 |
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| Abstract |
Streptococcus mutans, the primary etiological agent of human dental caries, possesses at least two fructose phosphotransferase systems (PTSs), encoded by fruI and fruCD. fruI is also responsible for xylitol transport. We hypothesized that fructose and xylitol transport systems do not affect virulence. Thus, colonization and cariogenicity of fruI(-) and fruCD(-) single and double mutants, their WT (UA159), and xylitol resistance (X(r)) of S. mutans were studied in rats fed a high-sucrose diet. A sucrose phosphorylase (gtfA(-)) mutant and a reference strain (NCTC-10449S) were additional controls. Recoveries of fruI mutant from the teeth were decreased, unlike those for the other strains. The fruCD mutation was associated with a slight loss of cariogenicity on enamel, whereas mutation of fruI was associated with a loss of cariogenicity in dentin. These results also suggest why xylitol inhibition of caries is paradoxically associated with spontaneous emergence of so-called X(r) S. mutans in habitual human xylitol users. |
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| Keywords |
Animals; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Biological Transport, Active; Colony Count, Microbial; Dental Caries/microbiology; Dental Caries/prevention & control; Dental Enamel/pathology; Dentin/pathology; Diet, Cariogenic; Fructose/metabolism; Gene Deletion; Genes, Bacterial; Glucosyltransferases/genetics; Glucosyltransferases/metabolism; Phosphoenolpyruvate Sugar Phosphotransferase System/genetics; Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism; Rats; Species Specificity; Streptococcus mutans/enzymology; Streptococcus mutans/genetics; Streptococcus mutans/pathogenicity; Virulence; Virulence Factors/genetics; Virulence Factors/metabolism; Xylitol/metabolism; Xylitol/therapeutic use |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0042489: negative regulation of odontogenesis of dentin-containing tooth |
ECO:0000315: |
P |
As seen in figure B and D, dentinal (Dm) scores for the fruI−-infected group were 30–35% lower than those of the WT- or gtfA−-infected groups when the data was pooled for the two trials, mutation of fruI was associated with a loss of cariogenicity in dentin. |
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