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PMID:16428423
| Citation |
Vivas, E, Skovran, E and Downs, DM (2006) Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo. J. Bacteriol. 188:1175-9 |
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| Abstract |
In Salmonella enterica, the isc operon contains genes necessary for the synthesis of Fe-S clusters and strains lacking this operon have severe defects in a variety of cellular processes. Other cellular loci that impact Fe-S cluster synthesis to a lesser extent have been described. The cyaY locus encodes a frataxin homolog, and it is shown here that lesions in this locus affect Fe-S cluster metabolism. When present in combination with other lesions, mutations in cyaY can result in a strain with more severe defects than those lacking the isc locus. |
| Links |
PubMed PMC1347345 Online version:10.1128/JB.188.3.1175-1179.2006 |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Escherichia coli Proteins; Iron-Binding Proteins/chemistry; Iron-Binding Proteins/genetics; Iron-Binding Proteins/metabolism; Iron-Sulfur Proteins/genetics; Iron-Sulfur Proteins/metabolism; Salmonella enterica/genetics; Salmonella enterica/growth & development; Salmonella enterica/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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