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PMID:16377706
| Citation |
Yin, S, Daum, RS and Boyle-Vavra, S (2006) VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus. Antimicrob. Agents Chemother. 50:336-43 |
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| Abstract |
The VraS/VraR two-component system (VraSR) regulates transcriptional induction of penicillin-binding protein 2 (encoded by pbp2) by vancomycin in Staphylococcus aureus. We have now defined the vraSR operon and determined that its induction by beta-lactams as well as by vancomycin is autoregulated. Induction of the pbp2 and vraSR operons by beta-lactams and related compounds within 1 hour after exposure to the antimicrobials was dependent on vraS. However, when a disk diffusion assay that can detect induction of genes over an extended time period was used, induction of the pbp2 operon was mediated by some beta-lactams, including oxacillin; this induction was independent of vraS. |
| Links |
PubMed PMC1346790 Online version:10.1128/AAC.50.1.336-343.2006 |
| Keywords |
Bacterial Proteins/metabolism; Cell Wall/chemistry; DNA-Binding Proteins; Drug Resistance, Multiple, Bacterial/genetics; Gene Expression Regulation, Bacterial/drug effects; Gene Expression Regulation, Bacterial/physiology; Microbial Sensitivity Tests; Operon; Penicillin-Binding Proteins; Signal Transduction; Staphylococcus aureus/chemistry; Staphylococcus aureus/metabolism; Staphylococcus aureus/physiology; Vancomycin/pharmacology |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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