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PMID:16289379
| Citation |
Maeda, N, Toku, S, Kenmochi, N and Tanaka, T (2006) A novel nucleolar protein interacts with ribosomal protein S19. Biochem. Biophys. Res. Commun. 339:41-6 |
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| Abstract |
The gene encoding ribosomal protein S19 (RPS19) is mutated in approximately 25% of patients with Diamond-Blackfan anemia (DBA), which is a rare congenital erythroblastopenia. DBA patients have a variety of clinical characteristics, and the role of the RPS19 gene in the pathogenesis of the disease is presently unknown. To investigate a possible role for RPS19 in erythropoiesis, we looked for proteins associated with mouse RPS19 using a yeast two-hybrid system and identified a novel protein, which we named S19 binding protein (S19BP). The deduced amino acid sequence of S19BP derived from cDNA defines a calculated mass of 15,849 and an isoelectric point of 11.3. No known functional motifs were found in S19BP except a short polylysine tract embedded in a putative nucleolar localization signal. Immunolocalization experiments revealed that S19BP was highly concentrated in nucleoli after 6 h of transfection in Cos-7 cells. S19BP was expressed ubiquitously at a basal level but a significantly high level of expression was observed in some tissues. |
| Links |
PubMed Online version:10.1016/j.bbrc.2005.10.184 |
| Keywords |
Amino Acid Sequence; Animals; COS Cells; Cell Nucleolus/metabolism; Cercopithecus aethiops; Mice; Molecular Sequence Data; Mutation; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Protein Binding; Ribosomal Proteins/genetics; Ribosomal Proteins/metabolism; Two-Hybrid System Techniques |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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