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PMID:16143134
| Citation |
Müerköster, S, Isberner, A, Arlt, A, Witt, M, Reimann, B, Blaszczuk, E, Werbing, V, Fölsch, UR, Schmitz, F and Schäfer, H (2005) Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. Gastroenterology 129:952-68 |
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| Abstract |
The role of amidated gastrin17 (G17) and the gastrin/CCKB/CCK2 receptor in colorectal carcinogenesis is still a controversial issue. Here, we investigated the effect of G17 on proliferation and apoptosis of CCK2 receptor-expressing human colon cancer cell lines in vitro and in vivo. |
| Links |
PubMed Online version:10.1053/j.gastro.2005.06.059 |
| Keywords |
Animals; Apoptosis/drug effects; Cell Division/drug effects; Cell Line, Tumor; Cell Survival/drug effects; Colonic Neoplasms/genetics; Colonic Neoplasms/pathology; Gastrins/pharmacology; Gene Expression Regulation, Neoplastic/drug effects; Humans; Mice; Mitochondria/drug effects; Mitochondria/physiology; RNA, Neoplasm/genetics; RNA, Neoplasm/isolation & purification; Receptor, Cholecystokinin B/drug effects; Receptor, Cholecystokinin B/genetics; Reverse Transcriptase Polymerase Chain Reaction; Transfection |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0015054: gastrin receptor activity |
ECO:0000314: |
F |
Figure 3 G17 Induces apotosis in human colon cancer cells expressing the wildtype but not the mutant CCK2 receptor |
complete | ||||
Notes
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References
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