GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:15998684
| Citation |
Matsui, R, Xu, S, Maitland, KA, Hayes, A, Leopold, JA, Handy, DE, Loscalzo, J and Cohen, RA (2005) Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation 112:257-63 |
|---|---|
| Abstract |
Glucose-6-phosphate dehydrogenase (G6PD) regulates production of the reduced form of NADPH through the pentose phosphate pathway. G6PD may therefore affect superoxide anion production via vascular NADPH oxidase, which is key in mediating the vascular response to angiotensin II (Ang II). We determined the hypertensive and vascular hypertrophic response to Ang II in G6PD-deficient mice. |
| Links |
PubMed Online version:10.1161/CIRCULATIONAHA.104.499095 |
| Keywords |
Angiotensin II/administration & dosage; Angiotensin II/pharmacology; Animals; Aorta/pathology; Blood Vessels/drug effects; Blood Vessels/physiopathology; Glucosephosphate Dehydrogenase Deficiency/physiopathology; Hypertension/etiology; Hypertrophy/etiology; Male; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 1/metabolism; Muscle, Smooth, Vascular/pathology; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Superoxides/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
