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PMID:15972537
| Citation |
Lee, JS, Heo, YJ, Lee, JK and Cho, YH (2005) KatA, the major catalase, is critical for osmoprotection and virulence in Pseudomonas aeruginosa PA14. Infect. Immun. 73:4399-403 |
|---|---|
| Abstract |
We demonstrate that among the three monofunctional catalases of Pseudomonas aeruginosa PA14, KatA and, to a lesser extent, KatB, but not KatE, are required for resistance to peroxide and osmotic stresses. KatA is crucial for adaptation to H2O2 stress and full virulence in both Drosophila melanogaster and mice. This dismantling of catalase roles represents a specialized catalytic system primarily involving KatA in responses to adverse environmental conditions. |
| Links |
PubMed PMC1168586 Online version:10.1128/IAI.73.7.4399-4403.2005 |
| Keywords |
Animals; Catalase/physiology; Drosophila melanogaster/microbiology; Hydrogen Peroxide/pharmacology; Potassium Chloride/pharmacology; Pseudomonas aeruginosa/drug effects; Pseudomonas aeruginosa/enzymology; Pseudomonas aeruginosa/pathogenicity; Virulence |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006979: response to oxidative stress |
ECO:0000315: |
P |
Fig. 2 |
complete | ||||
See also
References
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