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PMID:15927522
| Citation |
Shigeishi, H, Mizuta, K, Higashikawa, K, Yoneda, S, Ono, S and Kamata, N (2005) Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol. 41:716-22 |
|---|---|
| Abstract |
We examined the expression of Centromere protein F (CENP-F) mRNA in 26 human salivary gland tumors (seven pleomorphic adenomas, three Warthin tumors, seven mucoepidermoid carcinomas, four adenoid cystic carcinomas, four acinic cell carcinomas and one malignant myoepithelioma) and four normal submandibular glands using the real time quantitative reverse transcription-polymerase chain reaction (RT-PCR). The mean expression level of CENP-F mRNA was higher in malignant tumors (1.05+/-0.32) than normal submandibular glands (0.11+/-0.05) and benign tumors (0.46+/-0.16). We found a significant association between the level of CENP-F mRNA expression and clinical stage in 16 malignant tumors (Mann-Whitney U test, p=0.027). We also found a significant correlation between the Ki-67 labeling index and CENP-F expression in malignant tumors (Spearmans correlation coefficient by rank test, p=0.029). These results indicate that human CENP-F mRNA is closely linked to the increased or abnormal cell proliferation in malignant conditions. |
| Links |
PubMed Online version:10.1016/j.oraloncology.2005.03.008 |
| Keywords |
Adenoma/genetics; Adult; Aged; Aged, 80 and over; Cell Proliferation; Chromosomal Proteins, Non-Histone/genetics; Female; Gene Expression Regulation, Neoplastic/genetics; Humans; Male; Microfilament Proteins; Middle Aged; RNA, Messenger/metabolism; RNA, Neoplasm/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Salivary Gland Neoplasms/genetics; Submandibular Gland/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0008283: cell population proliferation |
ECO:0000303: author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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