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PMID:15862350
| Citation |
Koulen, P, Duncan, RS, Liu, J, Cohen, NE, Yannazzo, JA, McClung, N, Lockhart, CL, Branden, M and Buechner, M (2005) Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans. Cell Calcium 37:593-601 |
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| Abstract |
Polycystin-2, a member of the TRP family of calcium channels, is encoded by the human PKD2 gene. Mutations in that gene can lead to swelling of nephrons into the fluid-filled cysts of polycystic kidney disease. In addition to expression in tubular epithelial cells, human polycystin-2 is found in muscle and neuronal cells, but its cell biological function has been unclear. A homologue in Caenorhabditis elegans is necessary for male mating behavior. We compared the behavior, calcium signaling mechanisms, and electrophysiology of wild-type and pkd-2 knockout C. elegans. In addition to characterizing PKD-2-mediated aggregation and mating behaviors, we found that polycystin-2 is an intracellular Ca(2+) release channel that is required for the normal pattern of Ca(2+) responses involving IP(3) and ryanodine receptor-mediated Ca(2+) release from intracellular stores. Activity of polycystin-2 creates brief cytosolic Ca(2+) transients with increased amplitude and decreased duration. Polycystin-2, along with the IP(3) and ryanodine receptors, acts as a major calcium-release channel in the endoplasmic reticulum in cells where rapid calcium signaling is required, and polycystin-2 activity is essential in those excitable cells for rapid responses to stimuli. |
| Links |
PubMed Online version:10.1016/j.ceca.2005.03.003 |
| Keywords |
Amino Acid Sequence; Animals; Caenorhabditis elegans; Calcium/metabolism; Calcium Channels/metabolism; Calcium Signaling; Electrophysiology; Endoplasmic Reticulum/metabolism; Female; Humans; Inositol 1,4,5-Trisphosphate Receptors; Male; Membrane Proteins/genetics; Membrane Proteins/physiology; Molecular Sequence Data; Mutation; Neurons/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism; Ryanodine Receptor Calcium Release Channel/metabolism; Sexual Behavior, Animal/physiology; TRPP Cation Channels |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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