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PMID:15821992
| Citation |
Perales, M, Parisi, G, Fornasari, MS, Colaneri, A, Villarreal, F, González-Schain, N, Echave, J, Gómez-Casati, D, Braun, HP, Araya, A and Zabaleta, E (2004) Gamma carbonic anhydrase like complex interact with plant mitochondrial complex I. Plant Mol. Biol. 56:947-57 |
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| Abstract |
We report the identification by two hybrid screens of two novel similar proteins, called Arabidopsis thaliana gamma carbonic anhydrase like1 and 2 (AtgammaCAL1 and AtgammaCAL2), that interact specifically with putative Arabidopsis thaliana gamma Carbonic Anhydrase (AtgammaCA) proteins in plant mitochondria. The interaction region that was located in the N-terminal 150 amino acids of mature AtgammaCA and AtgammaCA like proteins represents a new interaction domain. In vitro experiments indicate that these proteins are imported into mitochondria and are associated with mitochondrial complex I as AtgammaCAs. All plant species analyzed contain both AtgammaCA and AtgammaCAL sequences indicating that these genes were conserved throughout plant evolution. Structural modeling of AtgammaCAL sequences show a deviation of functionally important active site residues with respect to gammaCAs but could form active interfaces in the interaction with AtgammaCAs. We postulate a CA complex tightly associated to plant mitochondrial complex. |
| Links |
PubMed Online version:10.1007/s11103-004-6324-z |
| Keywords |
Arabidopsis/cytology; Arabidopsis/genetics; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Binding Sites/genetics; Biological Transport; Carbonic Anhydrases/genetics; Carbonic Anhydrases/metabolism; Cells, Cultured; Dimerization; Electron Transport Complex I/genetics; Electron Transport Complex I/metabolism; Electrophoresis, Gel, Two-Dimensional; Genetic Variation; Isoenzymes/genetics; Isoenzymes/metabolism; Mitochondria/metabolism; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Models, Molecular; Oligopeptides/genetics; Phylogeny; Protein Binding; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid/genetics; Two-Hybrid System Techniques; Yeasts/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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