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PMID:15781740
| Citation |
Kinugawa, S, Wang, Z, Kaminski, PM, Wolin, MS, Edwards, JG, Kaley, G and Hintze, TH (2005) Limited exercise capacity in heterozygous manganese superoxide dismutase gene-knockout mice: roles of superoxide anion and nitric oxide. Circulation 111:1480-6 |
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| Abstract |
We have reported that there is a limitation of exercise capacity in mice with defects in the expression of endothelial nitric oxide (NO) synthase, which is associated with a greater increase in whole-body oxygen consumption (VO2). We hypothesized that in states in which superoxide anion (O2-) is increased, especially in the mitochondria, whole-body VO2 will be increased because of the inactivation of NO, and consequently, exercise capacity will be reduced. |
| Links |
PubMed Online version:10.1161/01.CIR.0000159261.11520.63 |
| Keywords |
Animals; Carbon Dioxide/metabolism; Cyclic N-Oxides/administration & dosage; Cyclic N-Oxides/pharmacology; Exercise Test; Free Radical Scavengers/administration & dosage; Free Radical Scavengers/pharmacology; Heterozygote; Male; Mice; Mice, Knockout; Muscle, Skeletal/enzymology; Muscle, Skeletal/metabolism; Nerve Tissue Proteins/analysis; Nitric Oxide/analysis; Nitric Oxide Synthase/analysis; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxygen Consumption/drug effects; Physical Endurance/drug effects; Physical Endurance/genetics; Spin Labels; Superoxide Dismutase/deficiency; Superoxide Dismutase/genetics; Superoxide Dismutase/physiology; Superoxides/analysis |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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