PMID:15620649

Citation	Sakata, T, Sakaguchi, H, Tsuda, L, Higashitani, A, Aigaki, T, Matsuno, K and Hayashi, S (2004) Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. Curr. Biol. 14:2228-36
Abstract	Ligand-induced proteolytic cleavage and internalization of the plasma membrane receptor Notch leads to its activation. Ligand-independent, steady-state internalization of Notch, however, does not lead to activation. The mechanism by which downstream effectors discriminate between these bipartite modes of Notch internalization is not understood. Nedd4 is a HECT domain-containing E3 ubiquitin ligase that targets transmembrane receptors containing the PPSY motif for endocytosis. Deltex is a positive Notch signaling regulator that encodes a putative ubiquitin ligase of the ring finger type.
Links	PubMed Online version:10.1016/j.cub.2004.12.028
Keywords	Animals; Cells, Cultured; Drosophila; Drosophila Proteins/metabolism; Endocytosis/physiology; Endosomal Sorting Complexes Required for Transport; Gene Expression Regulation/physiology; Homeodomain Proteins; Immunohistochemistry; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Membrane Proteins/metabolism; Models, Biological; Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Protein Transport/physiology; RNA Interference; Receptors, Notch; Signal Transduction/physiology; Transcription Factors; Ubiquitin/metabolism; Ubiquitin-Protein Ligases/metabolism; Ubiquitin-Protein Ligases/physiology; Wing/anatomy & histology; Wing/metabolism
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