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PMID:15608642
| Citation |
McCarty, N, Paust, S, Ikizawa, K, Dan, I, Li, X and Cantor, H (2005) Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat. Immunol. 6:65-72 |
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| Abstract |
Signaling through the T cell antigen receptor leading to elimination (negative selection) or differentiation (positive selection) of developing thymocytes generates a self-tolerant T cell repertoire. Here we report that the serine-threonine kinase MINK selectively connects the T cell receptor to a signaling pathway that mediates negative but not positive selection. Analysis of this pathway suggested that the essential function of MINK in the elimination of self-reactive thymocytes may be associated with 'downstream' activation of Jun kinase and enhancement of expression of the proapoptotic molecule Bim. |
| Links |
PubMed Online version:10.1038/ni1145 |
| Keywords |
Animals; Down-Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Potassium Channels, Voltage-Gated/genetics; Potassium Channels, Voltage-Gated/physiology; Receptors, Antigen, T-Cell/immunology; Signal Transduction/immunology; T-Lymphocyte Subsets/cytology; T-Lymphocyte Subsets/enzymology; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; Thymus Gland/cytology; Thymus Gland/enzymology; Thymus Gland/immunology; Thymus Gland/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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