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PMID:15608630
| Citation |
Torborg, CL, Hansen, KA and Feller, MB (2005) High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections. Nat. Neurosci. 8:72-8 |
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| Abstract |
Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation. |
| Links |
PubMed PMC1463890 Online version:10.1038/nn1376 |
| Keywords |
Action Potentials; Animals; Connexins/deficiency; Connexins/physiology; Electrophysiology; Geniculate Bodies/physiology; Mice; Mice, Knockout; Ocular Physiological Phenomena; Reaction Time; Receptors, Nicotinic/deficiency; Receptors, Nicotinic/physiology; Retina/physiology; Retinal Ganglion Cells/physiology; Synaptic Transmission/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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