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PMID:15565184
| Citation |
Seigel, GM, Wagner, J, Wronska, A, Campbell, L, Ju, W and Zhong, N (2005) Progression of early postnatal retinal pathology in a mouse model of neuronal ceroid lipofuscinosis. Eye (Lond) 19:1306-12 |
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| Abstract |
Accumulation of autofluorescent storage material in the CNS is a hallmark of neuronal ceroid lipofuscinosis (NCL, Batten disease). Since the retina is generally the first CNS target affected in NCL and could serve as a means to assess early disease progression as well as potential therapeutic responses, we followed the course of postnatal retinal pathology in tissues from the CLN8 (mnd) mouse model of NCL. |
| Links |
PubMed Online version:10.1038/sj.eye.6701770 |
| Keywords |
Aging/pathology; Animals; Cell Death; Disease Models, Animal; Disease Progression; Fluorescence; Hypertrophy/pathology; In Situ Nick-End Labeling; Inclusion Bodies/pathology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Fluorescence; Neuronal Ceroid-Lipofuscinoses/pathology; Retinal Degeneration/pathology; Retinal Ganglion Cells/pathology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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