PMID:15477346

Citation	Li, O, Zheng, P and Liu, Y (2004) CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J. Exp. Med. 200:1083-9
Abstract	It is well established that T lymphocytes undergo homeostatic proliferation in lymphopenic environment. The homeostatic proliferation requires recognition of the major histocompatibility complex on the host. Recent studies have demonstrated that costimulation-mediated CD28, 4-1BB, and CD40 is not required for T cell homeostatic proliferation. It has been suggested that homeostatic proliferation is costimulation independent. Here, we report that T cells from mice with a targeted mutation of CD24 have a remarkably reduced rate of proliferation when adoptively transferred into syngeneic lymphopenic hosts. The reduced proliferation cannot be attributed to abnormal survival and homing properties of the CD24-deficient T cells. T cell proliferation in allogeneic hosts is less affected by this mutation. These results demonstrate a novel function of CD24 expressed on T cells. Thus, although distinct costimulatory molecules are involved in antigen-driven proliferation and homeostatic proliferation, both processes can be modulated by costimulatory molecules.
Links	PubMed PMC2211842 Online version:10.1084/jem.20040779
Keywords	Adoptive Transfer; Animals; Antigens, CD/analysis; Antigens, CD/physiology; Antigens, CD24; Interferon-gamma/biosynthesis; L-Selectin/analysis; Lymphocyte Activation; Lymphopenia/immunology; Membrane Glycoproteins/analysis; Membrane Glycoproteins/physiology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes/immunology
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