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PMID:15229181
| Citation |
Gallio, M, Englund, C, Kylsten, P and Samakovlis, C (2004) Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development 131:3605-14 |
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| Abstract |
EGF-receptor ligands act as chemoattractants for migrating epithelial cells during organogenesis and wound healing. We present evidence that Rhomboid 3/EGF signalling, which originates from the midline of the Drosophila ventral nerve cord, repels tracheal ganglionic branches and prevents them from crossing it. rho3 acts independently from the main midline repellent Slit, and originates from a different sub-population of midline cells: the VUM neurons. Expression of dominant-negative Egfr or Ras induces midline crosses, whereas activation of the Egfr or Ras in the leading cell of the ganglionic branch can induce premature turns away from the midline. This suggests that the level of Egfr intracellular signalling, rather than the asymmetric activation of the receptor on the cell surface, is an important determinant in ganglionic branch repulsion. We propose that Egfr activation provides a necessary switch for the interpretation of a yet unknown repellent function of the midline. |
| Links |
PubMed Online version:10.1242/dev.01242 |
| Keywords |
Animals; Body Patterning; Central Nervous System/embryology; Central Nervous System/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/anatomy & histology; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Epidermal Growth Factor/metabolism; Eye Proteins/metabolism; In Situ Hybridization; Membrane Proteins/genetics; Membrane Proteins/metabolism; Morphogenesis; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Proto-Oncogene Proteins c-raf/metabolism; Receptor, Epidermal Growth Factor/metabolism; Repressor Proteins/metabolism; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism; Signal Transduction; Trachea/embryology; ras Proteins/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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