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PMID:15226356
| Citation |
Lin, L, Gerth, AJ and Peng, SL (2004) Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor. J. Exp. Med. 200:115-22 |
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| Abstract |
B cell terminal differentiation involves development into an antibody-secreting plasma cell, reflecting the concerted activation of proplasma cell transcriptional regulators, such as Blimp-1, IRF-4, and Xbp-1. Here, we show that the microphthalmia-associated transcription factor (Mitf) is highly expressed in naive B cells, where it antagonizes the process of terminal differentiation through the repression of IRF-4. Defective Mitf activity results in spontaneous B cell activation, antibody secretion, and autoantibody production. Conversely, ectopic Mitf expression suppresses the expression of IRF-4, the plasma cell marker CD138, and antibody secretion. Thus, Mitf regulates B cell homeostasis by suppressing the antibody-secreting fate. |
| Links |
PubMed PMC2213314 Online version:10.1084/jem.20040612 |
| Keywords |
Animals; Antibodies/metabolism; B-Lymphocytes/immunology; B-Lymphocytes/physiology; Cell Differentiation/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Homeostasis; Interferon Regulatory Factors; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microphthalmia-Associated Transcription Factor; Plasma Cells/physiology; Trans-Activators/genetics; Trans-Activators/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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