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PMID:15201909
| Citation |
Lim, MM, Wang, Z, Olazábal, DE, Ren, X, Terwilliger, EF and Young, LJ (2004) Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature 429:754-7 |
|---|---|
| Abstract |
The molecular mechanisms underlying the evolution of complex behaviour are poorly understood. The mammalian genus Microtus provides an excellent model for investigating the evolution of social behaviour. Prairie voles (Microtus ochrogaster) exhibit a monogamous social structure in nature, whereas closely related meadow voles (Microtus pennsylvanicus) are solitary and polygamous. In male prairie voles, both vasopressin and dopamine act in the ventral forebrain to regulate selective affiliation between adult mates, known as pair bond formation, as assessed by partner preference in the laboratory. The vasopressin V1a receptor (V1aR) is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. Here we substantially increase partner preference formation in the socially promiscuous meadow vole by using viral vector V1aR gene transfer into the ventral forebrain. We show that a change in the expression of a single gene in the larger context of pre-existing genetic and neural circuits can profoundly alter social behaviour, providing a potential molecular mechanism for the rapid evolution of complex social behaviour. |
| Links |
PubMed Online version:10.1038/nature02539 |
| Keywords |
Animals; Arvicolinae/genetics; Arvicolinae/physiology; Choice Behavior/physiology; Female; Male; Pair Bond; Prosencephalon/metabolism; Receptors, Dopamine/analysis; Receptors, Vasopressin/genetics; Receptors, Vasopressin/metabolism; Sexual Behavior, Animal/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0060179: male mating behavior |
ECO:0000315: |
P |
See figure 3. The more vasopressin receptors in the ventral pallidum, the more time the vole spends with the previously exposed female. |
complete | ||||
|
involved_in |
GO:0060179: male mating behavior |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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