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PMID:15136728
| Citation |
Zhu, Y, Swanson, BJ, Wang, M, Hildeman, DA, Schaefer, BC, Liu, X, Suzuki, H, Mihara, K, Kappler, J and Marrack, P (2004) Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc. Natl. Acad. Sci. U.S.A. 101:7681-6 |
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| Abstract |
Apoptosis in activated T cells in vivo requires the proapoptotic Bcl-2 family member Bim. We show here that, despite its ability to bind LC8, a component of the microtubule dynein motor complex, most of the Bim in both healthy and apoptotic T cells is associated with mitochondria, not microtubules. In healthy resting T cells Bim is bound to the antiapoptotic proteins Bcl-2 and Bcl-x(L). In activated T cells, levels of Bcl-2 fall, and Bim is associated more with Bcl-x(L) and less with Bcl-2. Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules. |
| Links |
PubMed PMC419666 Online version:10.1073/pnas.0402293101 |
| Keywords |
Animals; Apoptosis/physiology; Cell Membrane/metabolism; Fluorescent Antibody Technique; Mice; Mitochondria/metabolism; Mutation; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/metabolism; T-Lymphocytes/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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