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PMID:15063491
| Citation |
Huang, IH, Waters, M, Grau, RR and Sarker, MR (2004) Disruption of the gene (spo0A) encoding sporulation transcription factor blocks endospore formation and enterotoxin production in enterotoxigenic Clostridium perfringens type A. FEMS Microbiol. Lett. 233:233-40 |
|---|---|
| Abstract |
This study identified a functional spo0A ORF in enterotoxigenic Clostridium perfringens type A. To evaluate the function of spo0A, an isogenic spo0A knock-out mutant was constructed. The spo0A mutant was unable to form endospores and produce enterotoxin, however, these defects could be restored by complementing the mutant with a recombinant plasmid carrying the wild-type spo0A gene. These results provide evidence that spo0A expression is essential for sporulation and enterotoxin production in C. perfringens. |
| Links |
PubMed Online version:10.1016/j.femsle.2004.02.014 |
| Keywords |
Amino Acid Sequence; Bacterial Proteins/genetics; Base Sequence; Clostridium perfringens/genetics; Clostridium perfringens/growth & development; Clostridium perfringens/metabolism; Enterotoxins/metabolism; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Mutagenesis; Plasmids; Spores, Bacterial/genetics; Transcription Factors/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0034301: endospore formation |
ECO:0000315: |
P |
Figure 3. shows that spo0A knock-out mutant is unable to form endospores. |
complete | ||||
|
involved_in |
GO:0034301: endospore formation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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