PMID:14976192

Citation	Cakouros, D, Daish, TJ, Mills, K and Kumar, S (2004) An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells. J. Biol. Chem. 279:18467-71
Abstract	Developmentally programmed cell death is regulated by a balance between pro- and anti-death signaling. During Drosophila metamorphosis, the removal of larval tissues is dependent on the steroid hormone ecdysone, which controls the levels of pro- and anti-death molecules. Ecdysone binds to its heterodimeric receptor ecdysone receptor/ultraspiracle to mediate transcription of primary response genes. Here we show that CARMER, an arginine-histone methyltransferase, is critical in coordinating ecdysone-induced expression of Drosophila cell death genes. Ablation of CARMER blocks ecdysone-induced cell death in Drosophila cells, but not apoptosis induced by cell stress. We demonstrate that CARMER associates with the ecdysone receptor complex and modulates the ecdysone-induced transcription of a number of apoptotic genes. Thus, the chromatin-modifying protein, CARMER, modulates cell death by controlling the hormone-dependent expression of the core cell death machinery.
Links	PubMed Online version:10.1074/jbc.M400972200
Keywords	Amino Acid Sequence; Animals; Apoptosis/genetics; Drosophila/cytology; Ecdysone/physiology; Gene Expression Regulation, Developmental; Protein-Arginine N-Methyltransferases/metabolism; Protein-Arginine N-Methyltransferases/physiology; RNA, Messenger/analysis; Receptors, Steroid/metabolism; Sequence Alignment; Transcription, Genetic
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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