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PMID:14752159
| Citation |
Yoo, AS, Bais, C and Greenwald, I (2004) Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science 303:663-6 |
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| Abstract |
The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor-mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1 degrees fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2 degrees fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2 degrees cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal. |
| Links |
PubMed Online version:10.1126/science.1091639 |
| Keywords |
Animals; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Cycle Proteins/metabolism; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Helminth; Genes, Reporter; Green Fluorescent Proteins; Intercellular Signaling Peptides and Proteins/metabolism; Lac Operon; Luminescent Proteins/genetics; Luminescent Proteins/metabolism; MAP Kinase Signaling System; Membrane Proteins/metabolism; Mitogen-Activated Protein Kinases/metabolism; Models, Biological; Morphogenesis; Protein Tyrosine Phosphatases/metabolism; Receptor, Epidermal Growth Factor/metabolism; Recombinant Fusion Proteins; Signal Transduction; Stem Cells/cytology; Stem Cells/metabolism; Transcription, Genetic; Vulva/cytology; Vulva/growth & development; Vulva/metabolism |
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Significance
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