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PMID:1473153
| Citation |
Van Kaer, L, Ashton-Rickardt, PG, Ploegh, HL and Tonegawa, S (1992) TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell 71:1205-14 |
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| Abstract |
The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules. We have generated mice with a disrupted TAP1 gene using embryonic stem cell technology. TAP1-deficient mice are defective in the stable assembly and intracellular transport of class I molecules and consequently show severely reduced levels of surface class I molecules. These properties are strikingly similar to those described for the TAP2 mutant cell line RMA-S. Cells from the TAP1-deficient mice are unable to present cytosolic antigens to class I-restricted cytotoxic T cells. As predicted from the near absence of class I surface expression, TAP1-deficient mice lack CD4-8+ T cells. |
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| Keywords |
Animals; Antigens, CD4/genetics; Antigens, CD8/genetics; Base Sequence; Cell Line; Chimera; Gene Expression Regulation; Genes, MHC Class I/genetics; Mice; Mice, Transgenic; Molecular Sequence Data; T-Lymphocytes/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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