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PMID:14724296
| Citation |
Schaefer, BC, Kappler, JW, Kupfer, A and Marrack, P (2004) Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation. Proc. Natl. Acad. Sci. U.S.A. 101:1004-9 |
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| Abstract |
The central zone of the supramolecular activation cluster (c-SMAC) is a zone of T cell receptor (TCR) enrichment that forms at a T cell/antigen-presenting cell (APC) junction in response to antigen stimulation. We demonstrate that there is a surprisingly complex relocalization process that brings PKC and Bcl10, two intermediates in TCR activation of NF-kappaB, to the cytoplasmic face of the c-SMAC. TCR activation causes enrichment of PKC at the c-SMAC, followed by Bcl10 relocalization to punctate cytoplasmic structures, often at sites distant from the c-SMAC. These Bcl10 structures then undergo further relocalization, becoming enriched at the c-SMAC. TCR activation of NF-kappaB therefore involves the dynamic relocalization of multiple signaling intermediates, with distinct phases proximal to and distant from the c-SMAC. |
| Links |
PubMed PMC327141 Online version:10.1073/pnas.0307858100 |
| Keywords |
Adaptor Proteins, Signal Transducing; Animals; Antigen-Presenting Cells/immunology; Carrier Proteins/immunology; Mice; NF-kappa B/metabolism; Receptors, Antigen, T-Cell/immunology; Signal Transduction |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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