PMID:14687550

Citation	Grubb, MS, Rossi, FM, Changeux, JP and Thompson, ID (2003) Abnormal functional organization in the dorsal lateral geniculate nucleus of mice lacking the beta 2 subunit of the nicotinic acetylcholine receptor. Neuron 40:1161-72
Abstract	Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organization in the dorsal lateral geniculate nucleus (dLGN). Anatomical studies show normal gross retinotopy in the beta2(-/-) dLGN but suggest reduced topographic precision in the retinogeniculate projection. Physiological recordings reveal normal topography in the dorsoventral visual axis but a lack of fine-scale mapping in the nasotemporal visual plane. In contrast, unlike wild-type mice, on- and off-center cells in the beta2(-/-) dLGN are spatially segregated. The presence of the beta2 subunit of the nAChR in the CNS is therefore important for normal functional organization in the retinogeniculate projection.
Links	PubMed
Keywords	Action Potentials/physiology; Animals; Geniculate Bodies/growth & development; Geniculate Bodies/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Pathways/growth & development; Neural Pathways/metabolism; Protein Subunits/deficiency; Protein Subunits/genetics; Protein Subunits/physiology; Receptors, Nicotinic/deficiency; Receptors, Nicotinic/genetics; Receptors, Nicotinic/physiology; Retina/growth & development; Retina/metabolism
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