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PMID:14675533
| Citation |
Potuschak, T, Lechner, E, Parmentier, Y, Yanagisawa, S, Grava, S, Koncz, C and Genschik, P (2003) EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2. Cell 115:679-89 |
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| Abstract |
The plant hormone ethylene regulates a wide range of developmental processes and the response of plants to stress and pathogens. Genetic studies in Arabidopsis led to a partial elucidation of the mechanisms of ethylene action. Ethylene signal transduction initiates with ethylene binding at a family of ethylene receptors and terminates in a transcription cascade involving the EIN3/EIL and ERF families of plant-specific transcription factors. Here, we identify two Arabidopsis F box proteins called EBF1 and EBF2 that interact physically with EIN3/EIL transcription factors. EBF1 overexpression results in plants insensitive to ethylene. In contrast, plants carrying the ebf1 and ebf2 mutations display a constitutive ethylene response and accumulate the EIN3 protein in the absence of the hormone. Our work places EBF1 and EBF2 within the genetic framework of the ethylene-response pathway and supports a model in which ethylene action depends on EIN3 protein stabilization. |
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| Keywords |
Arabidopsis/drug effects; Arabidopsis/genetics; Arabidopsis/growth & development; Arabidopsis Proteins/genetics; Arabidopsis Proteins/isolation & purification; Arabidopsis Proteins/metabolism; Cell Nucleus/genetics; Cell Nucleus/metabolism; DNA, Complementary/analysis; DNA, Complementary/genetics; DNA-Binding Proteins; Ethylenes/metabolism; Ethylenes/pharmacology; F-Box Proteins/genetics; F-Box Proteins/isolation & purification; Gene Expression Regulation, Plant/drug effects; Gene Expression Regulation, Plant/genetics; Molecular Sequence Data; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Phenotype; Plant Proteins; Receptors, Cell Surface/metabolism; SKP Cullin F-Box Protein Ligases/genetics; SKP Cullin F-Box Protein Ligases/isolation & purification; Seedling/drug effects; Seedling/genetics; Seedling/growth & development; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Signal Transduction/drug effects; Signal Transduction/genetics; Transcription Factors |
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Significance
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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