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PMID:14579029
Citation |
Gual, P, Grémeaux, T, Gonzalez, T, Le Marchand-Brustel, Y and Tanti, JF (2003) MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 46:1532-42 |
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Abstract |
Insulin-induced IRS-1 serine phosphorylation could be physiologically important to regulate insulin action. In a hyperinsulinaemic state such as obesity or Type 2 diabetes, this phosphorylation could be modified and exacerbate insulin resistance. We aimed at identifying serine residues in IRS-1 phosphorylated in response to insulin stimulation and at determining the involved kinases. |
Links |
PubMed Online version:10.1007/s00125-003-1223-4 |
Keywords |
3T3 Cells; Amino Acid Sequence; Animals; Insulin/pharmacology; Insulin/physiology; Insulin Receptor Substrate Proteins; Mice; Mitogen-Activated Protein Kinases/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphoproteins/chemistry; Phosphoproteins/drug effects; Phosphoproteins/metabolism; Phosphorylation; Phosphoserine/metabolism; Protein Kinases/metabolism; Signal Transduction; TOR Serine-Threonine Kinases |
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Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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